The incident was reported just after 11 p.m. on Highway 29 near Kelseyville Auto Salvage, according to the California Highway Patrol.
Several CHP officers along with firefighters and sheriff's deputies responded to the scene, where a single vehicle was reported to be on fire and completely blocking the roadway.
Witnesses reported the vehicle had been involved in a traffic collision prior to the fire, according to the initial reports.
The fire also got into nearby vegetation but was reportedly quickly stopped by the first firefighters who arrived on scene.
Traffic was diverted while authorities handled the scene. A person was said to have been trapped in the vehicle, and a coroner later was summoned to handle a reported fatality.
Caltrans later reportedly responded to the scene, where CHP had opened one-way traffic just before midnight.
Other specifics about the incident were not immediately available early Sunday morning.
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